2021 Conference USA Leaders Scoring Defense - Games Lost Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Southern Mississippi | 9 | 39 | 8 | 39 | 0 | 1 | 299 | 33.2 |
| 2 | Florida Atlantic | 7 | 29 | 8 | 28 | 2 | 2 | 234 | 33.4 |
| 3 | Old Dominion | 7 | 30 | 11 | 28 | 1 | 0 | 243 | 34.7 |
| 4 | Louisiana Tech | 9 | 41 | 10 | 39 | 0 | 1 | 317 | 35.2 |
| 5 | Middle Tennessee | 6 | 28 | 6 | 27 | 1 | 1 | 217 | 36.2 |
| 5 | Marshall | 6 | 28 | 8 | 25 | 0 | 0 | 217 | 36.2 |
| 7 | UTEP | 6 | 26 | 12 | 25 | 0 | 1 | 219 | 36.5 |
| 8 | North Texas | 7 | 34 | 7 | 33 | 0 | 0 | 258 | 36.9 |
| 9 | UAB | 4 | 21 | 4 | 18 | 0 | 0 | 156 | 39.0 |
| 10 | Charlotte | 7 | 38 | 3 | 37 | 0 | 0 | 274 | 39.1 |
| 11 | Rice | 8 | 44 | 6 | 42 | 0 | 1 | 326 | 40.8 |
| 12 | UTSA | 2 | 11 | 2 | 11 | 0 | 0 | 83 | 41.5 |
| 13 | Florida International | 11 | 61 | 14 | 56 | 0 | 1 | 466 | 42.4 |
| 14 | Western Kentucky | 5 | 28 | 8 | 28 | 0 | 0 | 220 | 44.0 |