2021 Conference USA Leaders Scoring Defense - Games in December/January Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Middle Tennessee | 1 | 3 | 1 | 3 | 0 | 0 | 24 | 24.0 |
| 2 | North Texas | 1 | 3 | 2 | 3 | 0 | 0 | 27 | 27.0 |
| 3 | UAB | 1 | 4 | 0 | 4 | 0 | 0 | 28 | 28.0 |
| 4 | Old Dominion | 1 | 3 | 3 | 3 | 0 | 0 | 30 | 30.0 |
| 5 | UTEP | 1 | 3 | 3 | 2 | 0 | 1 | 31 | 31.0 |
| 6 | Marshall | 1 | 4 | 3 | 3 | 0 | 0 | 36 | 36.0 |
| 7 | UTSA | 2 | 10 | 3 | 8 | 1 | 0 | 79 | 39.5 |
| 8 | Western Kentucky | 2 | 12 | 1 | 12 | 0 | 0 | 87 | 43.5 |