2021 Conference USA Leaders Scoring Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | TD | FG | 1XP | 2XP | Safety | Points | Points/G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | UAB | 11 | 33 | 6 | 28 | 1 | 0 | 246 | 22.4 |
| 2 | Marshall | 12 | 38 | 12 | 35 | 0 | 0 | 299 | 24.9 |
| 3 | UTEP | 12 | 36 | 16 | 34 | 0 | 1 | 300 | 25.0 |
| 4 | Middle Tennessee | 11 | 35 | 12 | 34 | 1 | 1 | 284 | 25.8 |
| 5 | Florida Atlantic | 10 | 32 | 10 | 28 | 3 | 2 | 260 | 26.0 |
| 6 | UTSA | 12 | 41 | 11 | 34 | 1 | 0 | 315 | 26.3 |
| 7 | North Texas | 11 | 38 | 10 | 37 | 0 | 0 | 295 | 26.8 |
| 8 | Southern Mississippi | 10 | 33 | 13 | 33 | 0 | 1 | 272 | 27.2 |
| 9 | Western Kentucky | 11 | 41 | 8 | 39 | 0 | 0 | 309 | 28.1 |
| 10 | Old Dominion | 11 | 37 | 18 | 34 | 1 | 0 | 312 | 28.4 |
| 11 | Louisiana Tech | 9 | 38 | 10 | 35 | 1 | 1 | 297 | 33.0 |
| 12 | Rice | 9 | 40 | 8 | 38 | 0 | 1 | 304 | 33.8 |
| 13 | Charlotte | 9 | 47 | 6 | 44 | 1 | 0 | 346 | 38.4 |
| 14 | Florida International | 10 | 54 | 12 | 50 | 0 | 1 | 412 | 41.2 |