2021 Conference USA Leaders Opponent Penalties - Games Lost Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 9 | 65 | 649 | 7.2 | 72.1 |
| 2 | Southern Mississippi | 9 | 64 | 625 | 7.1 | 69.4 |
| 3 | Florida International | 11 | 57 | 543 | 5.2 | 49.4 |
| 4 | Florida Atlantic | 7 | 53 | 487 | 7.6 | 69.6 |
| 5 | North Texas | 7 | 51 | 460 | 7.3 | 65.7 |
| 5 | Charlotte | 7 | 51 | 436 | 7.3 | 62.3 |
| 7 | Rice | 8 | 50 | 492 | 6.3 | 61.5 |
| 8 | Old Dominion | 7 | 47 | 483 | 6.7 | 69.0 |
| 9 | UTEP | 6 | 36 | 395 | 6.0 | 65.8 |
| 10 | Middle Tennessee | 6 | 34 | 261 | 5.7 | 43.5 |
| 11 | Marshall | 6 | 33 | 313 | 5.5 | 52.2 |
| 12 | Western Kentucky | 5 | 26 | 230 | 5.2 | 46.0 |
| 13 | UAB | 4 | 18 | 177 | 4.5 | 44.3 |
| 14 | UTSA | 2 | 17 | 149 | 8.5 | 74.5 |