2021 Conference USA Leaders Opponent Penalties - Games in August/September Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Louisiana Tech | 4 | 37 | 341 | 9.3 | 85.3 |
| 2 | UTEP | 4 | 36 | 354 | 9.0 | 88.5 |
| 3 | North Texas | 4 | 30 | 296 | 7.5 | 74.0 |
| 4 | Southern Mississippi | 4 | 29 | 265 | 7.3 | 66.3 |
| 5 | Florida International | 4 | 28 | 285 | 7.0 | 71.3 |
| 5 | Rice | 4 | 28 | 275 | 7.0 | 68.8 |
| 7 | UAB | 4 | 26 | 235 | 6.5 | 58.8 |
| 7 | UTSA | 4 | 26 | 226 | 6.5 | 56.5 |
| 7 | Charlotte | 4 | 26 | 217 | 6.5 | 54.3 |
| 10 | Marshall | 4 | 25 | 194 | 6.3 | 48.5 |
| 11 | Old Dominion | 4 | 24 | 240 | 6.0 | 60.0 |
| 12 | Florida Atlantic | 4 | 22 | 192 | 5.5 | 48.0 |
| 13 | Middle Tennessee | 4 | 19 | 153 | 4.8 | 38.3 |
| 14 | Western Kentucky | 3 | 18 | 139 | 6.0 | 46.3 |