2021 Conference USA Leaders Total Defense - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UAB | 8 | 807 | 1648 | 505 | 2455 | 4.86 | 306.9 |
| 2 | UTEP | 7 | 948 | 1454 | 476 | 2402 | 5.05 | 343.1 |
| 3 | Southern Mississippi | 6 | 788 | 1341 | 345 | 2129 | 6.17 | 354.8 |
| 4 | North Texas | 7 | 1081 | 1490 | 474 | 2571 | 5.42 | 367.3 |
| 5 | Louisiana Tech | 6 | 974 | 1481 | 404 | 2455 | 6.08 | 409.2 |
| 6 | Old Dominion | 7 | 1031 | 1846 | 533 | 2877 | 5.40 | 411.0 |
| 7 | Middle Tennessee | 8 | 1291 | 2055 | 592 | 3346 | 5.65 | 418.3 |
| 8 | Marshall | 7 | 1698 | 1295 | 566 | 2993 | 5.29 | 427.6 |
| 9 | Rice | 6 | 1239 | 1440 | 363 | 2679 | 7.38 | 446.5 |
| 10 | UTSA | 7 | 1060 | 2153 | 510 | 3213 | 6.30 | 459.0 |
| 11 | Western Kentucky | 8 | 1493 | 2182 | 619 | 3675 | 5.94 | 459.4 |
| 12 | Florida Atlantic | 6 | 1321 | 1467 | 444 | 2788 | 6.28 | 464.7 |
| 13 | Charlotte | 6 | 1068 | 1728 | 384 | 2796 | 7.28 | 466.0 |
| 14 | Florida International | 6 | 1504 | 1697 | 441 | 3201 | 7.26 | 533.5 |