2021 Conference USA Leaders Total Defense - Games in November Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | North Texas | 4 | 480 | 737 | 235 | 1217 | 5.18 | 304.3 |
| 2 | Middle Tennessee | 4 | 323 | 938 | 257 | 1261 | 4.91 | 315.3 |
| 3 | UAB | 4 | 338 | 955 | 272 | 1293 | 4.75 | 323.3 |
| 4 | Western Kentucky | 4 | 398 | 1081 | 314 | 1479 | 4.71 | 369.8 |
| 5 | UTSA | 4 | 824 | 669 | 254 | 1493 | 5.88 | 373.3 |
| 6 | Southern Mississippi | 4 | 774 | 774 | 266 | 1548 | 5.82 | 387.0 |
| 7 | Marshall | 4 | 617 | 1012 | 297 | 1629 | 5.48 | 407.3 |
| 8 | Old Dominion | 4 | 531 | 1105 | 290 | 1636 | 5.64 | 409.0 |
| 9 | UTEP | 4 | 839 | 864 | 292 | 1703 | 5.83 | 425.8 |
| 10 | Louisiana Tech | 4 | 762 | 986 | 254 | 1748 | 6.88 | 437.0 |
| 11 | Florida Atlantic | 4 | 488 | 1323 | 286 | 1811 | 6.33 | 452.8 |
| 12 | Rice | 4 | 396 | 1456 | 269 | 1852 | 6.88 | 463.0 |
| 13 | Charlotte | 4 | 838 | 1172 | 276 | 2010 | 7.28 | 502.5 |
| 14 | Florida International | 4 | 1243 | 791 | 280 | 2034 | 7.26 | 508.5 |