2021 Conference USA Leaders Total Defense - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | UAB | 11 | 1216 | 2363 | 741 | 3579 | 4.83 | 325.4 |
| 2 | UTEP | 12 | 1687 | 2515 | 822 | 4202 | 5.11 | 350.2 |
| 3 | Southern Mississippi | 10 | 1595 | 1940 | 625 | 3535 | 5.66 | 353.5 |
| 4 | North Texas | 11 | 1456 | 2618 | 727 | 4074 | 5.60 | 370.4 |
| 5 | Middle Tennessee | 11 | 1456 | 2730 | 794 | 4186 | 5.27 | 380.5 |
| 6 | UTSA | 12 | 1367 | 3313 | 797 | 4680 | 5.87 | 390.0 |
| 7 | Old Dominion | 11 | 1476 | 2990 | 813 | 4466 | 5.49 | 406.0 |
| 8 | Florida Atlantic | 10 | 1457 | 2609 | 703 | 4066 | 5.78 | 406.6 |
| 9 | Marshall | 12 | 2425 | 2554 | 943 | 4979 | 5.28 | 414.9 |
| 10 | Louisiana Tech | 9 | 1663 | 2098 | 636 | 3761 | 5.91 | 417.9 |
| 11 | Rice | 9 | 1178 | 2609 | 585 | 3787 | 6.47 | 420.8 |
| 12 | Western Kentucky | 11 | 1831 | 2858 | 841 | 4689 | 5.58 | 426.3 |
| 13 | Charlotte | 9 | 1593 | 2774 | 578 | 4367 | 7.56 | 485.2 |
| 14 | Florida International | 10 | 2485 | 2552 | 741 | 5037 | 6.80 | 503.7 |