2021 Conference USA Leaders Total Offense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 9 | 904 | 3884 | 696 | 4788 | 6.88 | 532.0 |
| 2 | UTSA | 9 | 1816 | 2233 | 636 | 4049 | 6.37 | 449.9 |
| 3 | Marshall | 8 | 1243 | 2202 | 583 | 3445 | 5.91 | 430.6 |
| 4 | Charlotte | 8 | 1142 | 2203 | 565 | 3345 | 5.92 | 418.1 |
| 5 | North Texas | 8 | 2054 | 1252 | 627 | 3306 | 5.27 | 413.3 |
| 6 | UAB | 8 | 1479 | 1685 | 483 | 3164 | 6.55 | 395.5 |
| 7 | Old Dominion | 8 | 1246 | 1917 | 559 | 3163 | 5.66 | 395.4 |
| 8 | Florida Atlantic | 8 | 1146 | 2003 | 544 | 3149 | 5.79 | 393.6 |
| 9 | UTEP | 8 | 1071 | 2023 | 527 | 3094 | 5.87 | 386.8 |
| 10 | Rice | 8 | 1094 | 1828 | 561 | 2922 | 5.21 | 365.3 |
| 11 | Louisiana Tech | 8 | 896 | 1931 | 546 | 2827 | 5.18 | 353.4 |
| 12 | Middle Tennessee | 8 | 1097 | 1685 | 552 | 2782 | 5.04 | 347.8 |
| 13 | Florida International | 8 | 669 | 2061 | 501 | 2730 | 5.45 | 341.3 |
| 14 | Southern Mississippi | 8 | 953 | 1176 | 482 | 2129 | 4.42 | 266.1 |