2021 Conference USA Leaders Total Offense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Western Kentucky | 13 | 1363 | 5584 | 955 | 6947 | 7.27 | 534.4 |
| 2 | Marshall | 12 | 1918 | 3731 | 883 | 5649 | 6.40 | 470.8 |
| 3 | UTSA | 13 | 2448 | 3306 | 942 | 5754 | 6.11 | 442.6 |
| 4 | North Texas | 13 | 3043 | 2563 | 1033 | 5606 | 5.43 | 431.2 |
| 5 | UAB | 11 | 1992 | 2447 | 680 | 4439 | 6.53 | 403.5 |
| 5 | Charlotte | 12 | 1798 | 3044 | 822 | 4842 | 5.89 | 403.5 |
| 7 | Florida Atlantic | 12 | 1821 | 2975 | 835 | 4796 | 5.74 | 399.7 |
| 8 | UTEP | 13 | 1826 | 3283 | 849 | 5109 | 6.02 | 393.0 |
| 9 | Old Dominion | 12 | 1948 | 2662 | 836 | 4610 | 5.51 | 384.2 |
| 10 | Rice | 10 | 1587 | 2227 | 692 | 3814 | 5.51 | 381.4 |
| 11 | Louisiana Tech | 11 | 1328 | 2800 | 747 | 4128 | 5.53 | 375.3 |
| 12 | Florida International | 12 | 1225 | 3182 | 750 | 4407 | 5.88 | 367.3 |
| 13 | Middle Tennessee | 13 | 1608 | 3040 | 920 | 4648 | 5.05 | 357.5 |
| 14 | Southern Mississippi | 11 | 1367 | 1615 | 695 | 2982 | 4.29 | 271.1 |