2021 Conference USA Leaders Total Offense - Games Won Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Florida International | 1 | 318 | 276 | 49 | 594 | 12.12 | 594.0 |
| 2 | Western Kentucky | 9 | 1090 | 3684 | 667 | 4774 | 7.16 | 530.4 |
| 3 | Marshall | 7 | 1246 | 2276 | 525 | 3522 | 6.71 | 503.1 |
| 4 | Florida Atlantic | 5 | 1077 | 1415 | 357 | 2492 | 6.98 | 498.4 |
| 5 | North Texas | 6 | 1760 | 1109 | 461 | 2869 | 6.22 | 478.2 |
| 6 | UTSA | 12 | 2248 | 3145 | 880 | 5393 | 6.13 | 449.4 |
| 7 | Old Dominion | 6 | 1189 | 1504 | 424 | 2693 | 6.35 | 448.8 |
| 8 | Charlotte | 5 | 900 | 1322 | 336 | 2222 | 6.61 | 444.4 |
| 9 | Rice | 4 | 781 | 929 | 270 | 1710 | 6.33 | 427.5 |
| 10 | Louisiana Tech | 3 | 458 | 781 | 207 | 1239 | 5.99 | 413.0 |
| 11 | UTEP | 7 | 1184 | 1692 | 460 | 2876 | 6.25 | 410.9 |
| 12 | UAB | 9 | 1695 | 1911 | 569 | 3606 | 6.34 | 400.7 |
| 13 | Southern Mississippi | 3 | 796 | 381 | 186 | 1177 | 6.33 | 392.3 |
| 14 | Middle Tennessee | 7 | 1152 | 1418 | 498 | 2570 | 5.16 | 367.1 |