2021 Big 12 Conference Leaders Tackles For Loss - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Will McDonald IV | Iowa State | JR | DE | 4 | 5.0 | 33 | 1.25 |
| 2 | Taijh Alston | WVU | JR | DL | 4 | 4.5 | 26 | 1.13 |
| 3 | Brock Martin | Okla St | SR | DE | 4 | 4.5 | 22 | 1.13 |
| 4 | Isaiah Thomas | Oklahoma | SR | DL | 4 | 2.5 | 21 | 0.63 |
| 5 | Eyioma Uwazurike | Iowa State | SR | DE | 4 | 4.5 | 20 | 1.13 |
| 5 | Perrion Winfrey | Oklahoma | SR | DL | 4 | 4.0 | 20 | 1.00 |
| 5 | Tyree Wilson | Texas Tech | JR | DL | 4 | 4.0 | 20 | 1.00 |
| 5 | Jared Bartlett | WVU | SO | BAN | 4 | 4.0 | 20 | 1.00 |
| 5 | Jaylon Hutchings | Texas Tech | JR | DL | 4 | 3.0 | 20 | 0.75 |
| 10 | Tyler Lacy | Okla St | JR | DE | 4 | 3.5 | 19 | 0.88 |
| 10 | Dante Stills | WVU | SR | DL | 4 | 3.0 | 19 | 0.75 |
| 12 | Reggie Grimes | Oklahoma | SO | DE | 4 | 1.5 | 18 | 0.38 |
| 13 | Khalid Duke | Kansas St | JR | DE | 3 | 2.0 | 17 | 0.67 |
| 14 | Mike Rose | Iowa State | SR | LB | 4 | 6.0 | 16 | 1.50 |
| 14 | Felix Anudike-Uzomah | Kansas St | SO | DE | 4 | 4.0 | 16 | 1.00 |
| 14 | Devin Harper | Okla St | SR | LB | 4 | 2.5 | 16 | 0.63 |
| 17 | Ashton Logan | Baylor | SR | OLB | 4 | 3.5 | 15 | 0.88 |
| 17 | Jacob Morgenstern | Texas Tech | SR | LB | 4 | 1.0 | 15 | 0.25 |
| 19 | Matt Jones | Baylor | SO | LB | 4 | 3.0 | 14 | 0.75 |
| 19 | Jake Hummel | Iowa State | SR | LB | 4 | 3.0 | 14 | 0.75 |
| 21 | Jalen Pitre | Baylor | SR | S | 4 | 5.5 | 13 | 1.38 |
| 21 | Jahron McPherson | Kansas St | SR | DB | 4 | 4.5 | 13 | 1.13 |
| 21 | Jalen Redmond | Oklahoma | SO | DL | 3 | 2.5 | 13 | 0.83 |
| 21 | Dee Winters | TCU | JR | LB | 3 | 2.5 | 13 | 0.83 |
| 21 | Akheem Mesidor | WVU | SO | DL | 4 | 2.5 | 13 | 0.63 |
| 26 | Nik Bonitto | Oklahoma | JR | OLB | 4 | 3.5 | 11 | 0.88 |
| 26 | Alonzo Addae | WVU | SR | S | 4 | 3.0 | 11 | 0.75 |
| 26 | Tony Bradford Jr. | Texas Tech | JR | DL | 4 | 2.5 | 11 | 0.63 |
| 29 | Zach Petersen | Iowa State | SR | DE | 4 | 2.5 | 10 | 0.63 |
| 29 | Cody Fletcher | Kansas St | SR | LB | 4 | 2.5 | 10 | 0.63 |
| 31 | Ovie Oghoufo | Texas | JR | EDG | 4 | 3.0 | 9 | 0.75 |
| 31 | Sean Mahone | WVU | SR | S | 4 | 3.0 | 9 | 0.75 |
| 31 | Gerry Vaughn | Iowa State | JR | LB | 4 | 2.5 | 9 | 0.63 |
| 31 | Eli Huggins | Kansas St | SR | DT | 4 | 2.0 | 9 | 0.50 |
| 31 | Alfred Collins | Texas | SO | DL | 4 | 2.0 | 9 | 0.50 |
| 31 | Reggie Stubblefield | Kansas St | SR | DB | 3 | 1.0 | 9 | 0.33 |
| 31 | Jett Bush | Texas | JR | LB | 3 | 1.0 | 9 | 0.33 |
| 31 | Ben Kopenski | Okla St | JR | DE | 4 | 1.0 | 9 | 0.25 |
| 39 | Kyron Johnson | Kansas | SR | DE | 4 | 2.5 | 8 | 0.63 |
| 39 | Israel Antwine | Okla St | SR | DT | 3 | 2.0 | 8 | 0.67 |
| 39 | Ochaun Mathis | TCU | JR | DE | 3 | 2.0 | 8 | 0.67 |
| 39 | Terrel Bernard | Baylor | SR | LB | 4 | 1.5 | 8 | 0.38 |
| 39 | VanDarius Cowan | WVU | SR | BAN | 4 | 1.0 | 8 | 0.25 |
| 44 | Dillon Doyle | Baylor | JR | LB | 4 | 5.0 | 7 | 1.25 |
| 44 | Luke Brockermeyer | Texas | JR | LB | 4 | 3.0 | 7 | 0.75 |
| 44 | Jackie Matthews | WVU | JR | CB | 4 | 3.0 | 7 | 0.75 |
| 44 | Krishon Merriweather | Texas Tech | SR | LB | 4 | 2.5 | 7 | 0.63 |
| 44 | Colin Schooler | Texas Tech | SR | LB | 4 | 2.0 | 7 | 0.50 |
| 44 | Collin Oliver | Okla St | FR | DE | 4 | 1.5 | 7 | 0.38 |
| 44 | O'Rien Vance | Iowa State | SR | LB | 2 | 1.0 | 7 | 0.50 |