2021 Big 12 Conference Leaders Long All Purpose Plays - Games at Home Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Trestan Ebner | Baylor | SR | RB | 7 | 8 | 5 | 3 | 2 | 1 | 1 | 1 |
| 1 | Malik Knowles | Kansas St | JR | WR | 7 | 7 | 5 | 3 | 2 | 1 | 1 | 1 |
| 3 | Tahj Brooks | Texas Tech | SO | RB | 5 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 3 | Derius Davis | TCU | SR | WR | 7 | 5 | 5 | 2 | 2 | 1 | 1 | 1 |
| 3 | Erik Ezukanma | Texas Tech | JR | WR | 6 | 4 | 3 | 2 | 1 | 1 | 0 | 0 |
| 3 | Kaylon Geiger Sr. | Texas Tech | SR | WR | 6 | 3 | 2 | 2 | 0 | 0 | 0 | 0 |
| 3 | Daniel Imatorbhebhe | Kansas St | SR | TE | 7 | 2 | 2 | 2 | 2 | 1 | 0 | 0 |
| 3 | Kenny Logan Jr. | Kansas | JR | S | 6 | 2 | 2 | 2 | 2 | 1 | 1 | 0 |
| 3 | Marvin Mims | Oklahoma | SO | WR | 7 | 5 | 4 | 2 | 1 | 0 | 0 | 0 |
| 3 | JD Spielman | TCU | SR | WR | 4 | 5 | 3 | 2 | 1 | 1 | 1 | 0 |
| 3 | Caleb Williams | Oklahoma | FR | QB | 5 | 3 | 3 | 2 | 1 | 1 | 0 | 0 |
| 12 | Taye Barber | TCU | SR | WR | 7 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | LD Brown | Okla St | SR | RB | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 12 | Leddie Brown | WVU | SR | RB | 6 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 12 | Greg Eisworth II | Iowa State | SR | DB | 6 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Isaiah Esdale | WVU | SR | WR | 5 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Drew Estrada | Baylor | SR | WR | 6 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Zach Evans | TCU | SO | RB | 5 | 3 | 2 | 1 | 0 | 0 | 0 | 0 |
| 12 | Keenan Garber | Kansas St | SO | WR | 6 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Breece Hall | Iowa State | JR | RB | 6 | 6 | 2 | 1 | 1 | 1 | 1 | 0 |
| 12 | Xavier Hutchinson | Iowa State | SR | WR | 6 | 4 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Roschon Johnson | Texas | JR | RB | 6 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 12 | Quentin Johnston | TCU | SO | WR | 6 | 4 | 3 | 1 | 0 | 0 | 0 | 0 |
| 12 | Jaden Knowles | Oklahoma | JR | RB | 7 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Kendre Miller | TCU | SO | RB | 7 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Jaden Nixon | Okla St | FR | RB | 2 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Brennan Presley | Okla St | SO | WR | 7 | 7 | 2 | 1 | 1 | 1 | 1 | 1 |
| 12 | Dalton Rigdon | Texas Tech | SR | WR | 6 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Bijan Robinson | Texas | SO | RB | 5 | 4 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Keilan Robinson | Texas | JR | RB | 5 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Abram Smith | Baylor | SR | RB | 7 | 7 | 1 | 1 | 1 | 1 | 0 | 0 |
| 12 | SaRodorick Thompson | Texas Tech | JR | RB | 5 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 12 | Tyquan Thornton | Baylor | SR | WR | 7 | 4 | 4 | 1 | 1 | 1 | 0 | 0 |
| 12 | Deuce Vaughn | Kansas St | SO | RB | 7 | 5 | 3 | 1 | 1 | 0 | 0 | 0 |
| 12 | Jaylen Warren | Okla St | SR | RB | 7 | 2 | 2 | 1 | 0 | 0 | 0 | 0 |
| 12 | Marcus Washington | Texas | JR | WR | 6 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Marquis Waters | Texas Tech | SR | DB | 2 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 12 | Xavier White | Texas Tech | JR | RB | 6 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | JT Woods | Baylor | SR | S | 7 | 2 | 2 | 1 | 1 | 1 | 1 | 1 |
| 12 | Michael Woods II | Oklahoma | SR | WR | 6 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 12 | Xavier Worthy | Texas | FR | WR | 6 | 4 | 1 | 1 | 1 | 0 | 0 | 0 |
| 12 | Winston Wright Jr. | WVU | JR | WR | 6 | 2 | 1 | 1 | 1 | 1 | 1 | 1 |