2021 Big 12 Conference Leaders Long All Purpose Plays - Games in August/September Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Trestan Ebner | Baylor | SR | RB | 4 | 5 | 5 | 3 | 1 | 1 | 1 | 1 |
| 1 | Erik Ezukanma | Texas Tech | JR | WR | 4 | 6 | 3 | 3 | 1 | 1 | 0 | 0 |
| 3 | Kaylon Geiger Sr. | Texas Tech | SR | WR | 4 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |
| 3 | Malik Knowles | Kansas St | JR | WR | 4 | 4 | 3 | 2 | 1 | 1 | 1 | 1 |
| 3 | Deuce Vaughn | Kansas St | SO | RB | 4 | 2 | 2 | 2 | 0 | 0 | 0 | 0 |
| 3 | Jaylen Warren | Okla St | SR | RB | 4 | 2 | 2 | 2 | 1 | 1 | 0 | 0 |
| 3 | Winston Wright Jr. | WVU | JR | WR | 4 | 3 | 3 | 2 | 2 | 2 | 2 | 2 |
| 8 | Taye Barber | TCU | SR | WR | 3 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Phillip Brooks | Kansas St | JR | WR | 4 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 8 | Tahj Brooks | Texas Tech | SO | RB | 3 | 3 | 3 | 1 | 1 | 0 | 0 | 0 |
| 8 | LD Brown | Okla St | SR | RB | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Leddie Brown | WVU | SR | RB | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 8 | Ra'Mello Dotson | Kansas | FR | CB | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Zach Evans | TCU | SO | RB | 3 | 2 | 2 | 1 | 0 | 0 | 0 | 0 |
| 8 | Loic Fouonji | Texas Tech | SO | WR | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Daniel Imatorbhebhe | Kansas St | SR | TE | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Roschon Johnson | Texas | JR | RB | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Jaden Knowles | Oklahoma | JR | RB | 4 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 8 | Kwamie Lassiter II | Kansas | SR | WR | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Kenny Logan Jr. | Kansas | JR | S | 4 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 8 | Marvin Mims | Oklahoma | SO | WR | 4 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 8 | Devin Neal | Kansas | FR | RB | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Dalton Rigdon | Texas Tech | SR | WR | 4 | 2 | 1 | 1 | 0 | 0 | 0 | 0 |
| 8 | Bijan Robinson | Texas | SO | RB | 4 | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | Keilan Robinson | Texas | JR | RB | 4 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | R.J. Sneed | Baylor | SR | WR | 4 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 8 | JD Spielman | TCU | SR | WR | 3 | 4 | 2 | 1 | 0 | 0 | 0 | 0 |
| 8 | Marquis Waters | Texas Tech | SR | DB | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 8 | Xavier White | Texas Tech | JR | RB | 4 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 8 | Caleb Williams | Oklahoma | FR | QB | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
| 8 | JT Woods | Baylor | SR | S | 4 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 8 | Xavier Worthy | Texas | FR | WR | 4 | 3 | 1 | 1 | 1 | 0 | 0 | 0 |