2021 Big 12 Conference Leaders Passing - Games Lost Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Casey Thompson | Texas | JR | QB | 7 | 170 | 99 | 58.2 | 1293 | 7.6 | 14 | 5 | 143.43 | 24.3 | 184.7 |
| 2 | Max Duggan | TCU | JR | QB | 6 | 151 | 96 | 63.6 | 1337 | 8.9 | 11 | 3 | 158.02 | 25.2 | 222.8 |
| 3 | Brock Purdy | Iowa State | SR | QB | 6 | 209 | 136 | 65.1 | 1427 | 6.8 | 7 | 8 | 125.82 | 34.8 | 237.8 |
| 4 | Skylar Thompson | Kansas St | SR | QB | 3 | 93 | 59 | 63.4 | 684 | 7.4 | 5 | 1 | 140.81 | 31.0 | 228.0 |
| 4 | Jarret Doege | WVU | SR | QB | 7 | 231 | 149 | 64.5 | 1509 | 6.5 | 5 | 8 | 119.58 | 33.0 | 215.6 |
| 6 | Henry Colombi | Texas Tech | SR | QB | 4 | 94 | 58 | 61.7 | 893 | 9.5 | 4 | 4 | 147.03 | 23.5 | 223.3 |
| 6 | Jalon Daniels | Kansas | SO | QB | 5 | 87 | 60 | 69.0 | 658 | 7.6 | 4 | 3 | 140.77 | 17.4 | 131.6 |
| 6 | Jason Bean | Kansas | JR | QB | 10 | 156 | 85 | 54.5 | 1089 | 7.0 | 4 | 6 | 113.90 | 15.6 | 108.9 |
| 9 | Spencer Sanders | Okla St | JR | QB | 2 | 70 | 46 | 65.7 | 482 | 6.9 | 3 | 4 | 126.26 | 35.0 | 241.0 |
| 9 | Caleb Williams | Oklahoma | FR | QB | 2 | 57 | 29 | 50.9 | 394 | 6.9 | 3 | 2 | 119.29 | 28.5 | 197.0 |
| 9 | Gerry Bohanon | Baylor | JR | QB | 2 | 48 | 27 | 56.3 | 387 | 8.1 | 3 | 2 | 136.28 | 24.0 | 193.5 |
| 9 | Donovan Smith | Texas Tech | FR | QB | 6 | 75 | 42 | 56.0 | 544 | 7.3 | 3 | 1 | 127.46 | 12.5 | 90.7 |
| 9 | Hudson Card | Texas | FR | QB | 5 | 59 | 35 | 59.3 | 337 | 5.7 | 3 | 1 | 120.69 | 11.8 | 67.4 |
| 14 | Hunter Dekkers | Iowa State | FR | QB | 2 | 25 | 16 | 64.0 | 143 | 5.7 | 2 | 1 | 130.45 | 12.5 | 71.5 |
| 14 | Miles Kendrick | Kansas | SR | QB | 5 | 18 | 12 | 66.7 | 106 | 5.9 | 2 | 1 | 141.70 | 3.6 | 21.2 |
| 16 | Jaren Lewis | Kansas St | SO | QB | 2 | 20 | 10 | 50.0 | 148 | 7.4 | 1 | 2 | 108.66 | 10.0 | 74.0 |