2021 Big 12 Conference Leaders Passing - Games in November Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Jarret Doege | WVU | SR | QB | 4 | 131 | 85 | 64.9 | 837 | 6.4 | 8 | 4 | 132.60 | 32.8 | 209.3 |
| 2 | Jalon Daniels | Kansas | SO | QB | 4 | 111 | 78 | 70.3 | 811 | 7.3 | 7 | 3 | 147.04 | 27.8 | 202.8 |
| 2 | Casey Thompson | Texas | JR | QB | 4 | 86 | 53 | 61.6 | 559 | 6.5 | 7 | 3 | 136.11 | 21.5 | 139.8 |
| 4 | Brock Purdy | Iowa State | SR | QB | 4 | 151 | 110 | 72.8 | 1151 | 7.6 | 6 | 3 | 146.02 | 37.8 | 287.8 |
| 5 | Donovan Smith | Texas Tech | FR | QB | 3 | 85 | 50 | 58.8 | 674 | 7.9 | 5 | 1 | 142.48 | 28.3 | 224.7 |
| 5 | Spencer Sanders | Okla St | JR | QB | 4 | 124 | 76 | 61.3 | 870 | 7.0 | 5 | 3 | 128.69 | 31.0 | 217.5 |
| 5 | Gerry Bohanon | Baylor | JR | QB | 3 | 55 | 35 | 63.6 | 407 | 7.4 | 5 | 3 | 144.89 | 18.3 | 135.7 |
| 8 | Caleb Williams | Oklahoma | FR | QB | 3 | 75 | 37 | 49.3 | 481 | 6.4 | 4 | 3 | 112.80 | 25.0 | 160.3 |
| 9 | Hudson Card | Texas | FR | QB | 3 | 44 | 27 | 61.4 | 276 | 6.3 | 3 | 1 | 132.00 | 14.7 | 92.0 |
| 10 | Chandler Morris | TCU | FR | QB | 2 | 61 | 40 | 65.6 | 586 | 9.6 | 2 | 0 | 157.09 | 30.5 | 293.0 |
| 10 | Blake Shapen | Baylor | FR | QB | 2 | 55 | 36 | 65.5 | 391 | 7.1 | 2 | 0 | 137.18 | 27.5 | 195.5 |
| 10 | Max Duggan | TCU | JR | QB | 2 | 42 | 25 | 59.5 | 382 | 9.1 | 2 | 2 | 142.11 | 21.0 | 191.0 |
| 10 | Skylar Thompson | Kansas St | SR | QB | 3 | 72 | 48 | 66.7 | 540 | 7.5 | 2 | 0 | 138.84 | 24.0 | 180.0 |
| 14 | Hunter Dekkers | Iowa State | FR | QB | 1 | 9 | 5 | 55.6 | 29 | 3.2 | 1 | 1 | 97.07 | 9.0 | 29.0 |
| 14 | Xavier Hutchinson | Iowa State | SR | WR | 4 | 1 | 1 | 100.0 | 49 | 49.0 | 1 | 0 | 841.60 | 0.3 | 12.3 |