2021 Big 12 Conference Leaders Passing - Games vs. FBS (I-A) Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Casey Thompson | Texas | JR | QB | 12 | 261 | 165 | 63.2 | 2113 | 8.1 | 24 | 9 | 154.67 | 21.8 | 176.1 |
| 2 | Caleb Williams | Oklahoma | FR | QB | 10 | 201 | 131 | 65.2 | 1828 | 9.1 | 21 | 4 | 172.07 | 20.1 | 182.8 |
| 3 | Spencer Sanders | Okla St | JR | QB | 13 | 392 | 243 | 62.0 | 2831 | 7.2 | 20 | 12 | 133.37 | 30.2 | 217.8 |
| 4 | Brock Purdy | Iowa State | SR | QB | 12 | 381 | 271 | 71.1 | 2989 | 7.8 | 19 | 8 | 149.29 | 31.8 | 249.1 |
| 5 | Jarret Doege | WVU | SR | QB | 12 | 395 | 258 | 65.3 | 2789 | 7.1 | 16 | 12 | 131.92 | 32.9 | 232.4 |
| 6 | Max Duggan | TCU | JR | QB | 9 | 208 | 131 | 63.0 | 1841 | 8.9 | 15 | 5 | 156.32 | 23.1 | 204.6 |
| 6 | Gerry Bohanon | Baylor | JR | QB | 11 | 253 | 156 | 61.7 | 1947 | 7.7 | 15 | 7 | 140.35 | 23.0 | 177.0 |
| 8 | Skylar Thompson | Kansas St | SR | QB | 9 | 229 | 159 | 69.4 | 2017 | 8.8 | 12 | 3 | 158.09 | 25.4 | 224.1 |
| 9 | Jalon Daniels | Kansas | SO | QB | 6 | 117 | 81 | 69.2 | 860 | 7.4 | 7 | 3 | 145.58 | 19.5 | 143.3 |
| 9 | Donovan Smith | Texas Tech | FR | QB | 11 | 140 | 86 | 61.4 | 1188 | 8.5 | 7 | 2 | 146.35 | 12.7 | 108.0 |
| 11 | Spencer Rattler | Oklahoma | SO | QB | 8 | 161 | 120 | 74.5 | 1240 | 7.7 | 6 | 5 | 145.32 | 20.1 | 155.0 |
| 12 | Tyler Shough | Texas Tech | JR | QB | 3 | 70 | 52 | 74.3 | 698 | 10.0 | 5 | 1 | 178.76 | 23.3 | 232.7 |
| 12 | Henry Colombi | Texas Tech | SR | QB | 7 | 149 | 96 | 64.4 | 1291 | 8.7 | 5 | 5 | 141.57 | 21.3 | 184.4 |
| 12 | Blake Shapen | Baylor | FR | QB | 5 | 85 | 61 | 71.8 | 589 | 6.9 | 5 | 0 | 149.38 | 17.0 | 117.8 |
| 12 | Hudson Card | Texas | FR | QB | 8 | 83 | 51 | 61.4 | 590 | 7.1 | 5 | 1 | 138.63 | 10.4 | 73.8 |
| 16 | Jason Bean | Kansas | JR | QB | 10 | 156 | 85 | 54.5 | 1089 | 7.0 | 4 | 6 | 113.90 | 15.6 | 108.9 |
| 17 | Chandler Morris | TCU | FR | QB | 3 | 75 | 49 | 65.3 | 697 | 9.3 | 2 | 0 | 152.19 | 25.0 | 232.3 |
| 17 | Hunter Dekkers | Iowa State | FR | QB | 4 | 36 | 20 | 55.6 | 193 | 5.4 | 2 | 1 | 113.36 | 9.0 | 48.3 |
| 17 | Shane Illingworth | Okla St | SO | QB | 3 | 10 | 6 | 60.0 | 70 | 7.0 | 2 | 0 | 184.80 | 3.3 | 23.3 |
| 17 | Miles Kendrick | Kansas | SR | QB | 5 | 18 | 12 | 66.7 | 106 | 5.9 | 2 | 1 | 141.70 | 3.6 | 21.2 |
| 21 | Will Howard | Kansas St | SO | QB | 5 | 38 | 22 | 57.9 | 251 | 6.6 | 1 | 0 | 122.07 | 7.6 | 50.2 |
| 21 | Jaren Lewis | Kansas St | SO | QB | 4 | 23 | 12 | 52.2 | 154 | 6.7 | 1 | 2 | 105.38 | 5.8 | 38.5 |
| 21 | Xavier Hutchinson | Iowa State | SR | WR | 12 | 1 | 1 | 100.0 | 49 | 49.0 | 1 | 0 | 841.60 | 0.1 | 4.1 |
| 21 | Tyquan Thornton | Baylor | SR | WR | 13 | 1 | 1 | 100.0 | 6 | 6.0 | 1 | 0 | 480.40 | 0.1 | 0.5 |