2021 Big 12 Conference Leaders Interceptions - Games Lost Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Ra'Mello Dotson | Kansas | FR | CB | 10 | 1 | 65 | 0 | 0.10 |
| 2 | Wyatt Harris | TCU | JR | LB | 5 | 1 | 47 | 0 | 0.20 |
| 3 | B.J. Foster | Texas | SR | DB | 7 | 3 | 40 | 0 | 0.43 |
| 4 | Woodi Washington | Oklahoma | SO | CB | 2 | 2 | 32 | 0 | 1.00 |
| 5 | Gavin Potter | Kansas | JR | LB | 10 | 1 | 28 | 1 | 0.10 |
| 6 | Jake Hummel | Iowa State | SR | LB | 6 | 2 | 24 | 1 | 0.33 |
| 7 | Kenny Logan Jr. | Kansas | JR | S | 10 | 1 | 22 | 0 | 0.10 |
| 8 | Aric Horne | Iowa State | SO | LB | 5 | 1 | 14 | 0 | 0.20 |
| 9 | Luke Brockermeyer | Texas | JR | LB | 7 | 1 | 9 | 0 | 0.14 |
| 10 | Dillon Doyle | Baylor | JR | LB | 2 | 1 | 5 | 0 | 0.50 |
| 10 | Dee Winters | TCU | JR | LB | 7 | 1 | 5 | 0 | 0.14 |
| 12 | Craig McDonald | Iowa State | FR | DB | 6 | 2 | 2 | 0 | 0.33 |
| 12 | Raleigh Texada | Baylor | SR | CB | 2 | 1 | 2 | 0 | 0.50 |
| 14 | Sean Mahone | WVU | SR | S | 7 | 1 | 1 | 0 | 0.14 |