2021 Big 12 Conference Leaders Interceptions - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Jason Taylor II | Okla St | JR | S | 4 | 2 | 85 | 1 | 0.50 |
| 2 | Daryl Porter Jr. | WVU | FR | CB | 4 | 1 | 43 | 0 | 0.25 |
| 3 | JT Woods | Baylor | SR | S | 4 | 2 | 40 | 0 | 0.50 |
| 4 | Charles Woods | WVU | JR | CB | 4 | 1 | 32 | 0 | 0.25 |
| 5 | B.J. Foster | Texas | SR | DB | 4 | 2 | 31 | 0 | 0.50 |
| 6 | Tre'Vius Hodges-Tomlinson | TCU | JR | CB | 5 | 1 | 29 | 1 | 0.20 |
| 7 | Nick Session | Okla St | FR | S | 1 | 1 | 27 | 0 | 1.00 |
| 8 | Jake Hummel | Iowa State | SR | LB | 4 | 1 | 24 | 1 | 0.25 |
| 9 | Kenny Logan Jr. | Kansas | JR | S | 4 | 1 | 22 | 0 | 0.25 |
| 10 | Patrick Fields | Oklahoma | SR | S | 5 | 1 | 21 | 0 | 0.20 |
| 11 | Kolby Harvell-Peel | Okla St | SR | S | 4 | 1 | 20 | 0 | 0.25 |
| 12 | Greg Eisworth II | Iowa State | SR | DB | 4 | 1 | 18 | 0 | 0.25 |
| 13 | Tanner McCalister | Okla St | SR | S | 4 | 1 | 13 | 0 | 0.25 |
| 14 | Russ Yeast | Kansas St | SR | DB | 4 | 1 | 10 | 0 | 0.25 |
| 15 | Luke Brockermeyer | Texas | JR | LB | 4 | 1 | 9 | 0 | 0.25 |
| 15 | Dadrion Taylor-Demerson | Texas Tech | JR | DB | 5 | 1 | 9 | 0 | 0.20 |
| 17 | Dillon Doyle | Baylor | JR | LB | 4 | 1 | 5 | 0 | 0.25 |
| 18 | Raleigh Texada | Baylor | SR | CB | 4 | 1 | 2 | 0 | 0.25 |
| 18 | Justin Broiles | Oklahoma | SR | DB | 5 | 1 | 2 | 0 | 0.20 |
| 20 | Sean Mahone | WVU | SR | S | 4 | 1 | 1 | 0 | 0.25 |