2021 Big 12 Conference Leaders Interceptions - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Al Walcott | Baylor | JR | CB | 5 | 2 | 96 | 1 | 0.40 |
| 2 | JT Woods | Baylor | SR | S | 5 | 4 | 49 | 0 | 0.80 |
| 3 | B.J. Foster | Texas | SR | DB | 5 | 3 | 40 | 0 | 0.60 |
| 4 | Woodi Washington | Oklahoma | SO | CB | 3 | 2 | 32 | 0 | 0.67 |
| 5 | Brayden Utley | Baylor | JR | DL | 5 | 1 | 15 | 0 | 0.20 |
| 6 | Riko Jeffers | Texas Tech | SR | LB | 4 | 1 | 13 | 1 | 0.25 |
| 7 | Justin Broiles | Oklahoma | SR | DB | 3 | 1 | 12 | 0 | 0.33 |
| 8 | Malcolm Rodriguez | Okla St | SR | LB | 4 | 1 | 11 | 0 | 0.25 |
| 9 | Luke Brockermeyer | Texas | JR | LB | 5 | 1 | 9 | 0 | 0.20 |
| 10 | Dillon Doyle | Baylor | JR | LB | 5 | 1 | 5 | 0 | 0.20 |
| 11 | Raleigh Texada | Baylor | SR | CB | 5 | 1 | 2 | 0 | 0.20 |
| 11 | Craig McDonald | Iowa State | FR | DB | 5 | 1 | 2 | 0 | 0.20 |