2021 Big 12 Conference Leaders Rushing Defense - From Opponent's 40 to Own 40 Yard Line through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Long | 1st | 10+ | 20+ | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 14 | 101 | 262 | 2.59 | 1 | 55 | 18 | 9 | 2 |
| 2 | Baylor | 14 | 121 | 358 | 2.96 | 1 | 56 | 24 | 15 | 4 |
| 2 | Kansas State | 13 | 105 | 411 | 3.91 | 1 | 45 | 24 | 11 | 3 |
| 4 | Oklahoma | 13 | 104 | 330 | 3.17 | 0 | 50 | 25 | 10 | 3 |
| 5 | Texas Tech | 13 | 96 | 508 | 5.29 | 1 | 45 | 26 | 15 | 6 |
| 6 | Iowa State | 13 | 109 | 419 | 3.84 | 0 | 23 | 29 | 13 | 2 |
| 7 | Texas | 12 | 104 | 634 | 6.10 | 1 | 47 | 32 | 21 | 10 |
| 8 | TCU | 12 | 107 | 694 | 6.49 | 3 | 43 | 38 | 22 | 7 |
| 9 | West Virginia | 13 | 121 | 630 | 5.21 | 1 | 53 | 39 | 17 | 8 |
| 10 | Kansas | 12 | 134 | 1037 | 7.74 | 6 | 57 | 50 | 35 | 13 |
| 1st: First Downs; 10+: Rush attempts of 10 or more yards; 20+: Rush attempts of 20 or more yards | ||||||||||