2021 Big 12 Conference Leaders Rushing Defense - Games vs. Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | West Virginia | 9 | 285 | 1250 | 4.39 | 12 | 31.67 | 138.89 |
| 2 | Oklahoma State | 10 | 321 | 899 | 2.80 | 6 | 32.10 | 89.90 |
| 3 | Oklahoma | 9 | 312 | 1236 | 3.96 | 11 | 34.67 | 137.33 |
| 4 | Iowa State | 9 | 313 | 1310 | 4.19 | 9 | 34.78 | 145.56 |
| 5 | Baylor | 10 | 352 | 1207 | 3.43 | 12 | 35.20 | 120.70 |
| 6 | Texas Tech | 9 | 331 | 1569 | 4.74 | 16 | 36.78 | 174.33 |
| 7 | Kansas State | 9 | 336 | 1352 | 4.02 | 11 | 37.33 | 150.22 |
| 8 | TCU | 9 | 352 | 2120 | 6.02 | 30 | 39.11 | 235.56 |
| 9 | Texas | 9 | 362 | 1866 | 5.15 | 21 | 40.22 | 207.33 |
| 9 | Kansas | 9 | 362 | 2339 | 6.46 | 28 | 40.22 | 259.89 |