2021 Big 12 Conference Leaders Rushing Defense - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Texas Tech | 4 | 114 | 217 | 1.90 | 2 | 28.50 | 54.25 |
| 2 | Kansas State | 4 | 122 | 334 | 2.74 | 3 | 30.50 | 83.50 |
| 3 | Oklahoma | 4 | 130 | 441 | 3.39 | 4 | 32.50 | 110.25 |
| 4 | Oklahoma State | 4 | 132 | 328 | 2.48 | 3 | 33.00 | 82.00 |
| 5 | Iowa State | 4 | 136 | 280 | 2.06 | 2 | 34.00 | 70.00 |
| 6 | TCU | 3 | 108 | 544 | 5.04 | 4 | 36.00 | 181.33 |
| 6 | Texas | 3 | 108 | 553 | 5.12 | 5 | 36.00 | 184.33 |
| 8 | Baylor | 4 | 145 | 445 | 3.07 | 4 | 36.25 | 111.25 |
| 9 | West Virginia | 4 | 168 | 554 | 3.30 | 3 | 42.00 | 138.50 |
| 10 | Kansas | 3 | 133 | 659 | 4.95 | 12 | 44.33 | 219.67 |