2021 Big 12 Conference Leaders Rushing Defense - Games vs. FBS Teams With Winning Record Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 9 | 285 | 738 | 2.59 | 6 | 31.67 | 82.00 |
| 2 | Texas Tech | 7 | 227 | 731 | 3.22 | 7 | 32.43 | 104.43 |
| 3 | Iowa State | 7 | 245 | 972 | 3.97 | 8 | 35.00 | 138.86 |
| 3 | Oklahoma | 6 | 210 | 883 | 4.20 | 8 | 35.00 | 147.17 |
| 5 | Kansas State | 6 | 218 | 847 | 3.89 | 10 | 36.33 | 141.17 |
| 6 | West Virginia | 8 | 291 | 1224 | 4.21 | 11 | 36.38 | 153.00 |
| 7 | Baylor | 8 | 295 | 1017 | 3.45 | 11 | 36.88 | 127.13 |
| 8 | Kansas | 7 | 271 | 1803 | 6.65 | 26 | 38.71 | 257.57 |
| 9 | Texas | 8 | 311 | 1730 | 5.56 | 19 | 38.88 | 216.25 |
| 10 | TCU | 7 | 279 | 1845 | 6.61 | 25 | 39.86 | 263.57 |