2021 Big 12 Conference Leaders Total Defense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Oklahoma State | 10 | 899 | 1734 | 602 | 2633 | 4.37 | 263.3 |
| 2 | TCU | 10 | 2253 | 2556 | 647 | 4809 | 7.43 | 480.9 |
| 3 | Texas Tech | 10 | 1623 | 2779 | 680 | 4402 | 6.47 | 440.2 |
| 4 | Kansas | 10 | 2618 | 2494 | 685 | 5112 | 7.46 | 511.2 |
| 5 | Iowa State | 11 | 1505 | 2111 | 688 | 3616 | 5.26 | 328.7 |
| 6 | Kansas State | 11 | 1561 | 2316 | 703 | 3877 | 5.51 | 352.5 |
| 7 | Texas | 10 | 2199 | 2278 | 722 | 4477 | 6.20 | 447.7 |
| 8 | Oklahoma | 11 | 1522 | 2984 | 747 | 4506 | 6.03 | 409.6 |
| 9 | Baylor | 11 | 1345 | 2574 | 757 | 3919 | 5.18 | 356.3 |
| 10 | West Virginia | 12 | 1769 | 2690 | 769 | 4459 | 5.80 | 371.6 |