2022 Atlantic Coast Conference Leaders Total Defense - Games at Home Only through 01/09/2023
| Name | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Virginia Tech | 5 | 577 | 1119 | 331 | 1696 | 5.12 | 339.2 |
| 2 | Louisville | 6 | 715 | 1110 | 407 | 1825 | 4.48 | 304.2 |
| 3 | North Carolina State | 7 | 483 | 1603 | 428 | 2086 | 4.87 | 298.0 |
| 4 | Duke | 6 | 741 | 1357 | 385 | 2098 | 5.45 | 349.7 |
| 5 | Clemson | 7 | 524 | 1660 | 439 | 2184 | 4.97 | 312.0 |
| 6 | Florida State | 7 | 986 | 1203 | 467 | 2189 | 4.69 | 312.7 |
| 7 | Syracuse | 7 | 949 | 1244 | 451 | 2193 | 4.86 | 313.3 |
| 8 | Boston College | 6 | 982 | 1267 | 406 | 2249 | 5.54 | 374.8 |
| 9 | Virginia | 6 | 955 | 1296 | 433 | 2251 | 5.20 | 375.2 |
| 10 | North Carolina | 6 | 818 | 1436 | 420 | 2254 | 5.37 | 375.7 |
| 11 | Pittsburgh | 7 | 790 | 1551 | 470 | 2341 | 4.98 | 334.4 |
| 12 | Georgia Tech | 6 | 1069 | 1288 | 445 | 2357 | 5.30 | 392.8 |
| 13 | Miami (Florida) | 7 | 1054 | 1790 | 433 | 2844 | 6.57 | 406.3 |
| 14 | Wake Forest | 7 | 983 | 2012 | 521 | 2995 | 5.75 | 427.9 |