2021 Atlantic Coast Conference Leaders Opponent Penalties - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Florida State | 8 | 75 | 648 | 9.4 | 81.0 |
| 2 | Miami (Florida) | 8 | 61 | 553 | 7.6 | 69.1 |
| 3 | Pittsburgh | 11 | 82 | 756 | 7.5 | 68.7 |
| 4 | Wake Forest | 11 | 80 | 719 | 7.3 | 65.4 |
| 5 | Virginia | 8 | 55 | 519 | 6.9 | 64.9 |
| 6 | Clemson | 9 | 76 | 568 | 8.4 | 63.1 |
| 7 | Boston College | 9 | 63 | 527 | 7.0 | 58.6 |
| 8 | Georgia Tech | 8 | 50 | 458 | 6.3 | 57.3 |
| 9 | Duke | 10 | 66 | 556 | 6.6 | 55.6 |
| 10 | Virginia Tech | 11 | 67 | 597 | 6.1 | 54.3 |
| 11 | North Carolina State | 10 | 65 | 542 | 6.5 | 54.2 |
| 12 | North Carolina | 9 | 51 | 443 | 5.7 | 49.2 |
| 13 | Louisville | 8 | 40 | 323 | 5.0 | 40.4 |
| 14 | Syracuse | 8 | 28 | 279 | 3.5 | 34.9 |