2021 Atlantic Coast Conference Leaders Opponent Penalties - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Pen. | Yards | Pen./G | Yards/G | |
|---|---|---|---|---|---|---|
| 1 | Miami (Florida) | 10 | 80 | 760 | 8.0 | 76.0 |
| 2 | Wake Forest | 11 | 86 | 788 | 7.8 | 71.6 |
| 3 | Florida State | 9 | 76 | 638 | 8.4 | 70.9 |
| 4 | Clemson | 11 | 92 | 749 | 8.4 | 68.1 |
| 5 | Boston College | 9 | 66 | 594 | 7.3 | 66.0 |
| 6 | Pittsburgh | 11 | 82 | 714 | 7.5 | 64.9 |
| 7 | Virginia | 9 | 63 | 579 | 7.0 | 64.3 |
| 8 | North Carolina | 10 | 66 | 603 | 6.6 | 60.3 |
| 9 | North Carolina State | 9 | 66 | 521 | 7.3 | 57.9 |
| 10 | Virginia Tech | 10 | 63 | 554 | 6.3 | 55.4 |
| 11 | Georgia Tech | 9 | 49 | 477 | 5.4 | 53.0 |
| 12 | Duke | 10 | 62 | 518 | 6.2 | 51.8 |
| 13 | Louisville | 10 | 60 | 482 | 6.0 | 48.2 |
| 14 | Syracuse | 9 | 41 | 376 | 4.6 | 41.8 |