2021 Atlantic Coast Conference Leaders Passing Defense - Games in August/September Only through 01/10/2022
| Name | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | North Carolina State | 4 | 129 | 69 | 53.5 | 676 | 5.2 | 5 | 5 | 102.55 | 32.3 | 169.0 |
| 2 | Clemson | 4 | 136 | 84 | 61.8 | 708 | 5.2 | 4 | 3 | 110.80 | 34.0 | 177.0 |
| 3 | Virginia Tech | 4 | 123 | 73 | 59.3 | 761 | 6.2 | 5 | 5 | 116.60 | 30.8 | 190.3 |
| 4 | Wake Forest | 4 | 150 | 86 | 57.3 | 955 | 6.4 | 7 | 7 | 116.88 | 37.5 | 238.8 |
| 5 | Boston College | 4 | 114 | 71 | 62.3 | 762 | 6.7 | 4 | 6 | 119.48 | 28.5 | 190.5 |
| 6 | Pittsburgh | 4 | 125 | 72 | 57.6 | 822 | 6.6 | 6 | 2 | 125.48 | 31.3 | 205.5 |
| 7 | Georgia Tech | 4 | 101 | 62 | 61.4 | 679 | 6.7 | 5 | 2 | 130.24 | 25.3 | 169.8 |
| 8 | Miami (Florida) | 5 | 185 | 111 | 60.0 | 1251 | 6.8 | 10 | 3 | 131.40 | 37.0 | 250.2 |
| 9 | Duke | 4 | 122 | 69 | 56.6 | 963 | 7.9 | 7 | 5 | 133.60 | 30.5 | 240.8 |
| 10 | North Carolina | 4 | 125 | 79 | 63.2 | 945 | 7.6 | 6 | 3 | 137.74 | 31.3 | 236.3 |
| 11 | Louisville | 4 | 135 | 92 | 68.1 | 982 | 7.3 | 6 | 4 | 137.99 | 33.8 | 245.5 |
| 12 | Virginia | 5 | 140 | 80 | 57.1 | 1090 | 7.8 | 10 | 2 | 143.25 | 28.0 | 218.0 |
| 13 | Syracuse | 4 | 102 | 75 | 73.5 | 704 | 6.9 | 5 | 1 | 145.73 | 25.5 | 176.0 |
| 14 | Florida State | 4 | 144 | 90 | 62.5 | 1131 | 7.9 | 10 | 2 | 148.61 | 36.0 | 282.8 |