2021 Atlantic Coast Conference Leaders Interceptions - Games at Home Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Florida State | 7 | 7 | 124 | 1 | 1.00 |
| 2 | Pittsburgh | 7 | 6 | 113 | 2 | 0.86 |
| 3 | Louisville | 7 | 7 | 105 | 1 | 1.00 |
| 4 | Duke | 7 | 7 | 93 | 0 | 1.00 |
| 5 | Wake Forest | 6 | 8 | 91 | 0 | 1.33 |
| 6 | North Carolina | 7 | 9 | 71 | 0 | 1.29 |
| 7 | Virginia Tech | 7 | 6 | 70 | 1 | 0.86 |
| 8 | Clemson | 6 | 7 | 41 | 0 | 1.17 |
| 8 | Miami (Florida) | 7 | 4 | 41 | 0 | 0.57 |
| 10 | North Carolina State | 7 | 10 | 29 | 1 | 1.43 |
| 11 | Virginia | 7 | 5 | 27 | 0 | 0.71 |
| 12 | Boston College | 6 | 5 | 18 | 1 | 0.83 |
| 13 | Syracuse | 7 | 2 | 9 | 0 | 0.29 |
| 14 | Georgia Tech | 6 | 2 | 0 | 0 | 0.33 |