2021 Atlantic Coast Conference Leaders Interceptions - Games vs. FBS Teams With Non-Winning Record Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Duke | 8 | 8 | 101 | 0 | 1.00 |
| 2 | Florida State | 6 | 8 | 98 | 1 | 1.33 |
| 3 | Virginia | 6 | 5 | 93 | 0 | 0.83 |
| 4 | Miami (Florida) | 6 | 4 | 74 | 1 | 0.67 |
| 5 | Wake Forest | 9 | 10 | 64 | 0 | 1.11 |
| 5 | Louisville | 5 | 6 | 64 | 0 | 1.20 |
| 7 | Pittsburgh | 7 | 6 | 48 | 1 | 0.86 |
| 8 | Virginia Tech | 7 | 7 | 27 | 0 | 1.00 |
| 9 | North Carolina State | 7 | 10 | 23 | 1 | 1.43 |
| 9 | Syracuse | 6 | 2 | 23 | 0 | 0.33 |
| 11 | Clemson | 6 | 6 | 11 | 0 | 1.00 |
| 12 | Georgia Tech | 5 | 1 | 6 | 0 | 0.20 |
| 13 | Boston College | 8 | 7 | 5 | 0 | 0.88 |
| 14 | North Carolina | 5 | 3 | 1 | 0 | 0.60 |