2021 Atlantic Coast Conference Leaders Interceptions - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | G | Int. | Yards | TD | Int./G | |
|---|---|---|---|---|---|---|
| 1 | Wake Forest | 4 | 6 | 162 | 1 | 1.50 |
| 2 | Florida State | 4 | 6 | 103 | 1 | 1.50 |
| 3 | Virginia Tech | 5 | 4 | 81 | 1 | 0.80 |
| 4 | Louisville | 5 | 3 | 68 | 1 | 0.60 |
| 5 | Clemson | 5 | 7 | 60 | 1 | 1.40 |
| 5 | Pittsburgh | 5 | 3 | 60 | 1 | 0.60 |
| 7 | Duke | 4 | 5 | 55 | 0 | 1.25 |
| 8 | North Carolina State | 4 | 6 | 29 | 0 | 1.50 |
| 9 | North Carolina | 4 | 2 | 26 | 0 | 0.50 |
| 10 | Syracuse | 4 | 1 | 23 | 0 | 0.25 |
| 11 | Boston College | 4 | 6 | 15 | 1 | 1.50 |
| 12 | Georgia Tech | 4 | 2 | 0 | 0 | 0.50 |
| 12 | Miami (Florida) | 4 | 2 | 0 | 0 | 0.50 |
| 12 | Virginia | 4 | 2 | 0 | 0 | 0.50 |