2021 Atlantic Coast Conference Leaders First Downs - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Miami (Florida) | 4 | 22 | 55 | 15 | 92 | 23.0 |
| 2 | Wake Forest | 3 | 15 | 49 | 11 | 75 | 25.0 |
| 2 | Louisville | 5 | 45 | 45 | 11 | 101 | 20.2 |
| 4 | North Carolina | 4 | 48 | 40 | 9 | 97 | 24.3 |
| 4 | Syracuse | 4 | 41 | 31 | 9 | 81 | 20.3 |
| 4 | Clemson | 4 | 28 | 31 | 9 | 68 | 17.0 |
| 7 | North Carolina State | 2 | 16 | 33 | 7 | 56 | 28.0 |
| 8 | Virginia | 4 | 29 | 68 | 6 | 103 | 25.8 |
| 8 | Pittsburgh | 3 | 26 | 30 | 6 | 62 | 20.7 |
| 8 | Georgia Tech | 4 | 24 | 31 | 6 | 61 | 15.3 |
| 8 | Boston College | 3 | 19 | 20 | 6 | 45 | 15.0 |
| 12 | Virginia Tech | 2 | 13 | 17 | 4 | 34 | 17.0 |
| 12 | Florida State | 4 | 23 | 38 | 4 | 65 | 16.3 |
| 14 | Duke | 2 | 18 | 17 | 3 | 38 | 19.0 |