2021 Atlantic Coast Conference Leaders First Downs - Games on the Road/Neutral Site Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Wake Forest | 8 | 68 | 111 | 25 | 204 | 25.5 |
| 2 | Miami (Florida) | 5 | 38 | 69 | 21 | 128 | 25.6 |
| 3 | Clemson | 7 | 47 | 58 | 16 | 121 | 17.3 |
| 4 | Louisville | 6 | 61 | 65 | 11 | 137 | 22.8 |
| 5 | Virginia | 5 | 25 | 96 | 10 | 131 | 26.2 |
| 5 | Pittsburgh | 7 | 60 | 89 | 10 | 159 | 22.7 |
| 5 | Boston College | 6 | 54 | 51 | 10 | 115 | 19.2 |
| 5 | Florida State | 5 | 38 | 46 | 10 | 94 | 18.8 |
| 5 | Georgia Tech | 6 | 45 | 55 | 10 | 110 | 18.3 |
| 5 | Virginia Tech | 6 | 56 | 40 | 10 | 106 | 17.7 |
| 11 | Duke | 5 | 42 | 37 | 9 | 88 | 17.6 |
| 12 | Syracuse | 5 | 57 | 28 | 8 | 93 | 18.6 |
| 13 | North Carolina | 6 | 54 | 56 | 6 | 116 | 19.3 |
| 14 | North Carolina State | 5 | 25 | 63 | 4 | 92 | 18.4 |