2021 Atlantic Coast Conference Leaders First Downs - Games in October Only through 01/10/2022
| Name | G | Rush | Pass | Penalty | Total | Total/G | |
|---|---|---|---|---|---|---|---|
| 1 | Miami (Florida) | 3 | 20 | 40 | 15 | 75 | 25.0 |
| 2 | North Carolina | 4 | 51 | 38 | 10 | 99 | 24.8 |
| 3 | Wake Forest | 4 | 31 | 58 | 9 | 98 | 24.5 |
| 3 | Louisville | 4 | 40 | 35 | 9 | 84 | 21.0 |
| 3 | Georgia Tech | 4 | 30 | 43 | 9 | 82 | 20.5 |
| 6 | Virginia | 4 | 31 | 76 | 8 | 115 | 28.8 |
| 6 | Florida State | 4 | 41 | 32 | 8 | 81 | 20.3 |
| 6 | Clemson | 4 | 31 | 40 | 8 | 79 | 19.8 |
| 9 | Virginia Tech | 4 | 37 | 34 | 7 | 78 | 19.5 |
| 9 | Boston College | 4 | 27 | 34 | 7 | 68 | 17.0 |
| 11 | Pittsburgh | 4 | 35 | 64 | 6 | 105 | 26.3 |
| 12 | North Carolina State | 4 | 24 | 47 | 5 | 76 | 19.0 |
| 12 | Duke | 4 | 31 | 36 | 5 | 72 | 18.0 |
| 14 | Syracuse | 5 | 68 | 38 | 4 | 110 | 22.0 |