2021 American Athletic Conference Leaders Passing - Games vs. Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Clayton Tune | Houston | JR | QB | 9 | 275 | 187 | 68.0 | 2490 | 9.1 | 20 | 4 | 165.15 | 30.6 | 276.7 |
| 2 | Desmond Ridder | Cincinnati | SR | QB | 9 | 240 | 161 | 67.1 | 2145 | 8.9 | 21 | 6 | 166.04 | 26.7 | 238.3 |
| 3 | Seth Henigan | Memphis | FR | QB | 7 | 275 | 163 | 59.3 | 2152 | 7.8 | 16 | 7 | 139.11 | 39.3 | 307.4 |
| 3 | Holton Ahlers | ECU | JR | QB | 8 | 276 | 176 | 63.8 | 2152 | 7.8 | 13 | 5 | 141.18 | 34.5 | 269.0 |
| 5 | Tanner Mordecai | SMU | JR | QB | 8 | 315 | 210 | 66.7 | 2360 | 7.5 | 19 | 7 | 145.07 | 39.4 | 295.0 |
| 6 | Michael Pratt | Tulane | FR | QB | 8 | 204 | 117 | 57.4 | 1499 | 7.3 | 11 | 6 | 130.98 | 25.5 | 187.4 |
| 7 | Davis Brin | Tulsa | JR | QB | 8 | 243 | 140 | 57.6 | 1750 | 7.2 | 11 | 11 | 124.00 | 30.4 | 218.8 |
| 8 | Timmy McClain | S Florida | FR | QB | 7 | 192 | 105 | 54.7 | 1330 | 6.9 | 4 | 5 | 114.54 | 27.4 | 190.0 |
| 9 | Mikey Keene | UCF | FR | QB | 8 | 214 | 132 | 61.7 | 1323 | 6.2 | 13 | 6 | 128.05 | 26.8 | 165.4 |
Note: To qualify, player must have played in 75% of his team's games and have a minimum of 15.0 pass attempts per game played.