2021 American Athletic Conference Leaders Passing - Games vs. Non-Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Mikey Keene | UCF | FR | QB | 3 | 58 | 41 | 70.7 | 407 | 7.0 | 4 | 0 | 152.39 | 19.3 | 135.7 |
| 2 | Seth Henigan | Memphis | FR | QB | 4 | 118 | 72 | 61.0 | 1170 | 9.9 | 9 | 1 | 167.79 | 29.5 | 292.5 |
| 2 | D'Wan Mathis | Temple | FR | QB | 2 | 56 | 30 | 53.6 | 440 | 7.9 | 2 | 1 | 127.78 | 28.0 | 220.0 |
| 4 | Desmond Ridder | Cincinnati | SR | QB | 5 | 147 | 90 | 61.2 | 1189 | 8.1 | 9 | 2 | 146.64 | 29.4 | 237.8 |
| 4 | Michael Pratt | Tulane | FR | QB | 4 | 124 | 72 | 58.1 | 882 | 7.1 | 10 | 2 | 141.20 | 31.0 | 220.5 |
| 4 | Timmy McClain | S Florida | FR | QB | 4 | 70 | 40 | 57.1 | 558 | 8.0 | 1 | 2 | 123.11 | 17.5 | 139.5 |
| 4 | Cade Fortin | S Florida | SO | QB | 2 | 38 | 19 | 50.0 | 132 | 3.5 | 0 | 2 | 68.65 | 19.0 | 66.0 |
| 8 | Dillon Gabriel | UCF | JR | QB | 3 | 102 | 70 | 68.6 | 814 | 8.0 | 9 | 3 | 158.90 | 34.0 | 271.3 |
| 9 | Tanner Mordecai | SMU | JR | QB | 4 | 139 | 98 | 70.5 | 1268 | 9.1 | 20 | 5 | 187.41 | 34.8 | 317.0 |
| 9 | Davis Brin | Tulsa | JR | QB | 5 | 168 | 104 | 61.9 | 1494 | 8.9 | 7 | 5 | 144.41 | 33.6 | 298.8 |
| 9 | Holton Ahlers | ECU | JR | QB | 4 | 138 | 80 | 58.0 | 978 | 7.1 | 5 | 5 | 122.21 | 34.5 | 244.5 |
| 12 | Clayton Tune | Houston | JR | QB | 5 | 145 | 100 | 69.0 | 1056 | 7.3 | 10 | 6 | 144.63 | 29.0 | 211.2 |
Note: To qualify, player must have and have a minimum of 15.0 pass attempts per game played.