2021 American Athletic Conference Leaders Passing - Games in August/September Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Seth Henigan | Memphis | FR | QB | 4 | 118 | 72 | 61.0 | 1170 | 9.9 | 9 | 1 | 167.79 | 29.5 | 292.5 |
| 1 | D'Wan Mathis | Temple | FR | QB | 2 | 56 | 30 | 53.6 | 440 | 7.9 | 2 | 1 | 127.78 | 28.0 | 220.0 |
| 3 | Desmond Ridder | Cincinnati | SR | QB | 3 | 83 | 54 | 65.1 | 748 | 9.0 | 7 | 2 | 163.77 | 27.7 | 249.3 |
| 3 | Michael Pratt | Tulane | FR | QB | 4 | 124 | 72 | 58.1 | 882 | 7.1 | 10 | 2 | 141.20 | 31.0 | 220.5 |
| 3 | Timmy McClain | S Florida | FR | QB | 4 | 70 | 40 | 57.1 | 558 | 8.0 | 1 | 2 | 123.11 | 17.5 | 139.5 |
| 3 | Cade Fortin | S Florida | SO | QB | 2 | 38 | 19 | 50.0 | 132 | 3.5 | 0 | 2 | 68.65 | 19.0 | 66.0 |
| 7 | Dillon Gabriel | UCF | JR | QB | 3 | 102 | 70 | 68.6 | 814 | 8.0 | 9 | 3 | 158.90 | 34.0 | 271.3 |
| 8 | Tanner Mordecai | SMU | JR | QB | 4 | 139 | 98 | 70.5 | 1268 | 9.1 | 20 | 5 | 187.41 | 34.8 | 317.0 |
| 8 | Davis Brin | Tulsa | JR | QB | 4 | 134 | 82 | 61.2 | 1209 | 9.0 | 5 | 5 | 141.82 | 33.5 | 302.3 |
| 8 | Holton Ahlers | ECU | JR | QB | 4 | 138 | 80 | 58.0 | 978 | 7.1 | 5 | 5 | 122.21 | 34.5 | 244.5 |
| 8 | Clayton Tune | Houston | JR | QB | 4 | 105 | 75 | 71.4 | 729 | 6.9 | 5 | 5 | 135.94 | 26.3 | 182.3 |
Note: To qualify, player must have and have a minimum of 15.0 pass attempts per game played.