2021 American Athletic Conference Leaders Passing - Games in October Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Timmy McClain | S Florida | FR | QB | 3 | 60 | 34 | 56.7 | 442 | 7.4 | 1 | 0 | 124.05 | 20.0 | 147.3 |
| 2 | Clayton Tune | Houston | JR | QB | 4 | 126 | 86 | 68.3 | 1110 | 8.8 | 11 | 1 | 169.47 | 31.5 | 277.5 |
| 2 | Holton Ahlers | ECU | JR | QB | 4 | 136 | 85 | 62.5 | 1005 | 7.4 | 6 | 1 | 137.67 | 34.0 | 251.3 |
| 4 | Desmond Ridder | Cincinnati | SR | QB | 5 | 142 | 89 | 62.7 | 1099 | 7.7 | 11 | 2 | 150.43 | 28.4 | 219.8 |
| 5 | Tanner Mordecai | SMU | JR | QB | 4 | 161 | 113 | 70.2 | 1357 | 8.4 | 12 | 3 | 161.85 | 40.3 | 339.3 |
| 5 | Seth Henigan | Memphis | FR | QB | 3 | 109 | 66 | 60.6 | 983 | 9.0 | 7 | 3 | 151.99 | 36.3 | 327.7 |
| 5 | D'Wan Mathis | Temple | FR | QB | 4 | 127 | 79 | 62.2 | 746 | 5.9 | 4 | 3 | 117.23 | 31.8 | 186.5 |
| 5 | Michael Pratt | Tulane | FR | QB | 4 | 88 | 53 | 60.2 | 716 | 8.1 | 6 | 3 | 144.25 | 22.0 | 179.0 |
| 5 | Katravis Marsh | S Florida | SO | QB | 2 | 37 | 19 | 51.4 | 217 | 5.9 | 1 | 3 | 93.32 | 18.5 | 108.5 |
| 5 | Peter Parrish | Memphis | SO | QB | 2 | 48 | 31 | 64.6 | 215 | 4.5 | 0 | 3 | 89.70 | 24.0 | 107.5 |
| 11 | Davis Brin | Tulsa | JR | QB | 4 | 123 | 67 | 54.5 | 861 | 7.0 | 6 | 6 | 119.61 | 30.8 | 215.3 |
| 11 | Mikey Keene | UCF | FR | QB | 5 | 128 | 81 | 63.3 | 805 | 6.3 | 9 | 6 | 129.93 | 25.6 | 161.0 |
Note: To qualify, player must have and have a minimum of 15.0 pass attempts per game played.