2021 American Athletic Conference Leaders Total Offense - Games vs. Ranked Teams Only (AP Poll) through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Davis Brin | Tulsa | JR | QB | 4 | -6 | 1070 | 173 | 1064 | 6.15 | 266.0 |
| 2 | Timmy McClain | S Florida | FR | QB | 4 | 130 | 846 | 152 | 976 | 6.42 | 244.0 |
| 3 | Michael Pratt | Tulane | FR | QB | 4 | 23 | 676 | 134 | 699 | 5.22 | 174.8 |
| 4 | Desmond Ridder | Cincinnati | SR | QB | 3 | 39 | 631 | 108 | 670 | 6.20 | 223.3 |
| 5 | Holton Ahlers | ECU | JR | QB | 2 | -22 | 506 | 94 | 484 | 5.15 | 242.0 |
| 6 | Tanner Mordecai | SMU | JR | QB | 2 | -18 | 371 | 75 | 353 | 4.71 | 176.5 |
| 7 | Clayton Tune | Houston | JR | QB | 1 | 21 | 250 | 49 | 271 | 5.53 | 271.0 |
| 8 | Seth Henigan | Memphis | FR | QB | 1 | 20 | 208 | 52 | 228 | 4.38 | 228.0 |
| 9 | Justin Lynch | Temple | FR | QB | 2 | 107 | 149 | 46 | 256 | 5.57 | 128.0 |
| 10 | Mikey Keene | UCF | FR | QB | 1 | 0 | 141 | 29 | 141 | 4.86 | 141.0 |
| 11 | D'Wan Mathis | Temple | FR | QB | 1 | -10 | 120 | 37 | 110 | 2.97 | 110.0 |
| 12 | Tai Lavatai | Navy | SO | QB | 2 | 15 | 116 | 46 | 131 | 2.85 | 65.5 |
| 13 | Xavier Arline | Navy | SO | QB | 2 | 72 | 101 | 35 | 173 | 4.94 | 86.5 |
| 14 | Kai Horton | Tulane | FR | QB | 2 | -16 | 79 | 24 | 63 | 2.63 | 31.5 |
| 15 | Cade Fortin | S Florida | SO | QB | 1 | 23 | 41 | 25 | 64 | 2.56 | 64.0 |
| 16 | Maasai Maynor | Navy | JR | QB | 1 | -11 | 15 | 3 | 4 | 1.33 | 4.0 |
| 17 | Christian Daniels | Tulane | SO | WR | 2 | 29 | 14 | 6 | 43 | 7.17 | 21.5 |
| 18 | Gabriel Rogers | Memphis | SR | WR | 1 | 22 | 8 | 2 | 30 | 15.00 | 30.0 |