2021 American Athletic Conference Leaders Total Offense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Rush Yards | Pass Yards | Plays | Total Yards | Yards/Play | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Davis Brin | Tulsa | JR | QB | 2 | 14 | 652 | 92 | 666 | 7.24 | 333.0 |
| 2 | Michael Pratt | Tulane | FR | QB | 2 | 71 | 462 | 88 | 533 | 6.06 | 266.5 |
| 3 | Clayton Tune | Houston | JR | QB | 2 | 71 | 457 | 98 | 528 | 5.39 | 264.0 |
| 4 | Desmond Ridder | Cincinnati | SR | QB | 2 | 39 | 354 | 88 | 393 | 4.47 | 196.5 |
| 5 | Tanner Mordecai | SMU | JR | QB | 1 | 37 | 245 | 32 | 282 | 8.81 | 282.0 |
| 6 | Timmy McClain | S Florida | FR | QB | 2 | 27 | 209 | 35 | 236 | 6.74 | 118.0 |
| 7 | Dillon Gabriel | UCF | JR | QB | 1 | 18 | 184 | 39 | 202 | 5.18 | 202.0 |
| 8 | Justin Lynch | Temple | FR | QB | 2 | 66 | 161 | 54 | 227 | 4.20 | 113.5 |
| 9 | Seth Henigan | Memphis | FR | QB | 1 | 3 | 159 | 32 | 162 | 5.06 | 162.0 |
| 10 | D'Wan Mathis | Temple | FR | QB | 1 | 6 | 148 | 33 | 154 | 4.67 | 154.0 |
| 11 | Mikey Keene | UCF | FR | QB | 1 | -19 | 144 | 25 | 125 | 5.00 | 125.0 |
| 12 | Cade Fortin | S Florida | SO | QB | 2 | 17 | 132 | 45 | 149 | 3.31 | 74.5 |
| 13 | Holton Ahlers | ECU | JR | QB | 1 | 4 | 77 | 34 | 81 | 2.38 | 81.0 |
| 14 | Tyler Snead | ECU | SO | WR | 1 | 0 | 75 | 1 | 75 | 75.00 | 75.0 |
| 15 | Ryan O'Keefe | UCF | JR | WR | 2 | 110 | 20 | 5 | 130 | 26.00 | 65.0 |
| 16 | Katravis Marsh | S Florida | SO | QB | 1 | 0 | 14 | 1 | 14 | 14.00 | 14.0 |
| 17 | Parker Navarro | UCF | FR | QB | 1 | 3 | 4 | 3 | 7 | 2.33 | 7.0 |