2021 American Athletic Conference Leaders Passing - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | Team | Yr | Pos | G | Att | Comp | Pct. | Yards | Yards/Att | TD | Int | Rating | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Michael Pratt | Tulane | FR | QB | 2 | 62 | 37 | 59.7 | 462 | 7.5 | 5 | 0 | 148.89 | 31.0 | 231.0 |
| 2 | Tanner Mordecai | SMU | JR | QB | 1 | 28 | 17 | 60.7 | 245 | 8.8 | 4 | 3 | 159.92 | 28.0 | 245.0 |
| 2 | Clayton Tune | Houston | JR | QB | 2 | 78 | 53 | 67.9 | 457 | 5.9 | 4 | 5 | 121.27 | 39.0 | 228.5 |
| 4 | Dillon Gabriel | UCF | JR | QB | 1 | 29 | 22 | 75.9 | 184 | 6.3 | 3 | 1 | 156.40 | 29.0 | 184.0 |
| 5 | Davis Brin | Tulsa | JR | QB | 2 | 81 | 50 | 61.7 | 652 | 8.0 | 2 | 2 | 132.55 | 40.5 | 326.0 |
| 5 | Seth Henigan | Memphis | FR | QB | 1 | 28 | 16 | 57.1 | 159 | 5.7 | 2 | 1 | 121.27 | 28.0 | 159.0 |
| 7 | Desmond Ridder | Cincinnati | SR | QB | 2 | 68 | 37 | 54.4 | 354 | 5.2 | 1 | 1 | 100.05 | 34.0 | 177.0 |
| 7 | Mikey Keene | UCF | FR | QB | 1 | 22 | 14 | 63.6 | 144 | 6.5 | 1 | 0 | 133.62 | 22.0 | 144.0 |
| 7 | Tyler Snead | ECU | SO | WR | 1 | 1 | 1 | 100.0 | 75 | 75.0 | 1 | 0 | 1060.00 | 1.0 | 75.0 |
| 7 | Ryan O'Keefe | UCF | JR | WR | 2 | 1 | 1 | 100.0 | 20 | 20.0 | 1 | 0 | 598.00 | 0.5 | 10.0 |