2021 American Athletic Conference Leaders Passes Defended - Games at Home Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | UCF | 7 | 9 | 38 | 47 | 6.71 |
| 2 | East Carolina | 6 | 10 | 37 | 47 | 7.83 |
| 3 | Memphis | 7 | 6 | 30 | 36 | 5.14 |
| 4 | SMU | 6 | 8 | 23 | 31 | 5.17 |
| 5 | Cincinnati | 7 | 7 | 22 | 29 | 4.14 |
| 5 | Tulsa | 6 | 5 | 22 | 27 | 4.50 |
| 7 | South Florida | 6 | 7 | 16 | 23 | 3.83 |
| 8 | Houston | 5 | 3 | 15 | 18 | 3.60 |
| 9 | Navy | 6 | 5 | 14 | 19 | 3.17 |
| 9 | Temple | 6 | 3 | 14 | 17 | 2.83 |
| 11 | Tulane | 6 | 8 | 11 | 19 | 3.17 |