2021 American Athletic Conference Leaders Passes Defended - Games in November Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | Houston | 4 | 7 | 21 | 28 | 7.00 |
| 2 | UCF | 4 | 4 | 20 | 24 | 6.00 |
| 3 | Memphis | 4 | 7 | 19 | 26 | 6.50 |
| 4 | Cincinnati | 4 | 3 | 18 | 21 | 5.25 |
| 5 | Temple | 4 | 2 | 16 | 18 | 4.50 |
| 6 | Tulsa | 4 | 4 | 15 | 19 | 4.75 |
| 6 | East Carolina | 4 | 3 | 15 | 18 | 4.50 |
| 6 | SMU | 4 | 3 | 15 | 18 | 4.50 |
| 9 | Tulane | 4 | 4 | 10 | 14 | 3.50 |
| 10 | South Florida | 4 | 2 | 5 | 7 | 1.75 |
| 11 | Navy | 3 | 0 | 4 | 4 | 1.33 |