2021 American Athletic Conference Leaders Passes Defended - Games vs. FBS non-Power 5 Conference Teams Only through 01/10/2022
| Name | G | Int. | Passes Broken Up | Passes Defended | Passes Defended/G | |
|---|---|---|---|---|---|---|
| 1 | UCF | 10 | 9 | 41 | 50 | 5.00 |
| 2 | Cincinnati | 11 | 12 | 40 | 52 | 4.73 |
| 3 | Memphis | 10 | 8 | 39 | 47 | 4.70 |
| 4 | Houston | 11 | 14 | 38 | 52 | 4.73 |
| 5 | Tulsa | 10 | 9 | 35 | 44 | 4.40 |
| 6 | East Carolina | 10 | 13 | 33 | 46 | 4.60 |
| 7 | SMU | 10 | 7 | 31 | 38 | 3.80 |
| 8 | Temple | 9 | 4 | 29 | 33 | 3.67 |
| 9 | Navy | 12 | 7 | 27 | 34 | 2.83 |
| 10 | Tulane | 9 | 6 | 24 | 30 | 3.33 |
| 11 | South Florida | 9 | 7 | 17 | 24 | 2.67 |