2021 American Athletic Conference Leaders Rushing Offense - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | Navy | 9 | 520 | 2157 | 4.15 | 15 | 57.78 | 239.67 |
| 2 | Tulsa | 9 | 397 | 1972 | 4.97 | 17 | 44.11 | 219.11 |
| 3 | UCF | 12 | 439 | 2397 | 5.46 | 25 | 36.58 | 199.75 |
| 4 | Cincinnati | 11 | 379 | 2040 | 5.38 | 31 | 34.45 | 185.45 |
| 5 | Tulane | 8 | 294 | 1457 | 4.96 | 14 | 36.75 | 182.13 |
| 6 | East Carolina | 10 | 402 | 1809 | 4.50 | 19 | 40.20 | 180.90 |
| 7 | South Florida | 8 | 342 | 1413 | 4.13 | 17 | 42.75 | 176.63 |
| 8 | SMU | 10 | 367 | 1754 | 4.78 | 18 | 36.70 | 175.40 |
| 9 | Houston | 13 | 468 | 1906 | 4.07 | 27 | 36.00 | 146.62 |
| 10 | Memphis | 11 | 388 | 1539 | 3.97 | 18 | 35.27 | 139.91 |
| 11 | Temple | 10 | 308 | 1132 | 3.68 | 11 | 30.80 | 113.20 |