2021 American Athletic Conference Leaders Rushing Offense - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | Att | Yards | Avg. | TD | Att/G | Yards/G | |
|---|---|---|---|---|---|---|---|---|
| 1 | SMU | 1 | 52 | 350 | 6.73 | 2 | 52.00 | 350.00 |
| 2 | UCF | 2 | 84 | 500 | 5.95 | 3 | 42.00 | 250.00 |
| 3 | Tulane | 2 | 70 | 239 | 3.41 | 3 | 35.00 | 119.50 |
| 4 | East Carolina | 1 | 38 | 116 | 3.05 | 1 | 38.00 | 116.00 |
| 5 | South Florida | 2 | 73 | 213 | 2.92 | 2 | 36.50 | 106.50 |
| 6 | Tulsa | 2 | 67 | 196 | 2.93 | 2 | 33.50 | 98.00 |
| 7 | Houston | 2 | 61 | 192 | 3.15 | 1 | 30.50 | 96.00 |
| 7 | Cincinnati | 2 | 62 | 192 | 3.10 | 3 | 31.00 | 96.00 |
| 9 | Temple | 2 | 72 | 191 | 2.65 | 2 | 36.00 | 95.50 |
| 10 | Memphis | 1 | 25 | 87 | 3.48 | 0 | 25.00 | 87.00 |