2021 American Athletic Conference Leaders Tackles For Loss - Games vs. Unranked Teams Only (AP Poll) through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Houston | 13 | 95.0 | 387 | 7.31 |
| 2 | UCF | 12 | 85.0 | 349 | 7.08 |
| 3 | Cincinnati | 11 | 76.0 | 271 | 6.91 |
| 4 | Memphis | 11 | 61.0 | 255 | 5.55 |
| 5 | Tulane | 8 | 64.0 | 238 | 8.00 |
| 6 | SMU | 10 | 55.0 | 225 | 5.50 |
| 7 | Temple | 10 | 64.0 | 217 | 6.40 |
| 8 | East Carolina | 10 | 53.0 | 184 | 5.30 |
| 9 | Tulsa | 9 | 54.0 | 167 | 6.00 |
| 10 | Navy | 9 | 44.0 | 164 | 4.89 |
| 11 | South Florida | 8 | 37.0 | 115 | 4.63 |