2021 American Athletic Conference Leaders Tackles For Loss - Games vs. FBS Power 5 Conference Teams Only through 01/10/2022
| Name | G | TFL | TFL Yards | TFL/G | |
|---|---|---|---|---|---|
| 1 | Tulane | 2 | 14.0 | 61 | 7.00 |
| 2 | Houston | 2 | 12.0 | 47 | 6.00 |
| 2 | Tulsa | 2 | 12.0 | 47 | 6.00 |
| 4 | Temple | 2 | 15.0 | 45 | 7.50 |
| 5 | East Carolina | 1 | 7.0 | 32 | 7.00 |
| 6 | Cincinnati | 2 | 12.0 | 28 | 6.00 |
| 7 | South Florida | 2 | 6.0 | 24 | 3.00 |
| 8 | Memphis | 1 | 4.0 | 23 | 4.00 |
| 9 | SMU | 1 | 3.0 | 22 | 3.00 |
| 10 | UCF | 2 | 8.0 | 21 | 4.00 |