2021 Big Ten Conference Leaders Long All Purpose Plays - Games vs. Conference Teams Only through 01/10/2022
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| Name | Team | Yr | Pos | G | Yards | Yards | Yards | Yards | Yards | Yards | Yards | |
| 1 | Jalen Nailor | Mich St | JR | WR | 5 | 4 | 4 | 3 | 3 | 0 | 0 | 0 |
| 2 | Braelon Allen | Wisconsin | FR | RB | 9 | 7 | 3 | 3 | 2 | 2 | 0 | 0 |
| 2 | TreVeyon Henderson | Ohio State | FR | RB | 9 | 5 | 4 | 3 | 2 | 1 | 0 | 0 |
| 2 | Charlie Jones | Iowa | SR | WR | 10 | 9 | 4 | 2 | 2 | 2 | 1 | 1 |
| 2 | Samori Toure | Nebraska | SR | WR | 9 | 6 | 4 | 3 | 2 | 2 | 0 | 0 |
| 2 | Kenneth Walker III | Mich St | JR | RB | 9 | 8 | 4 | 4 | 2 | 2 | 1 | 1 |
| 7 | Andrel Anthony | Michigan | FR | WR | 8 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 7 | Chris Autman-Bell | Minnesota | SR | WR | 8 | 3 | 1 | 1 | 1 | 0 | 0 | 0 |
| 7 | David Bell | Purdue | JR | WR | 8 | 7 | 5 | 3 | 1 | 0 | 0 | 0 |
| 7 | Zavier Betts | Nebraska | FR | WR | 9 | 2 | 1 | 1 | 1 | 1 | 1 | 0 |
| 7 | Stephan Bracey | Wisconsin | SO | WR | 2 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| 7 | Ji'Ayir Brown | Penn State | SR | S | 9 | 1 | 1 | 1 | 1 | 1 | 1 | 0 |
| 7 | Stephen Carr | Indiana | SR | RB | 6 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 7 | Blake Corum | Michigan | SO | RB | 8 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 7 | Aron Cruickshank | Rutgers | JR | WR | 4 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Danny Davis III | Wisconsin | SR | WR | 9 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Jahan Dotson | Penn State | SR | WR | 9 | 9 | 4 | 1 | 1 | 1 | 1 | 0 |
| 7 | Donovan Edwards | Michigan | FR | RB | 8 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Emeka Egbuka | Ohio State | FR | WR | 7 | 5 | 3 | 1 | 1 | 0 | 0 | 0 |
| 7 | Tyler Goodson | Iowa | JR | RB | 10 | 5 | 4 | 3 | 1 | 0 | 0 | 0 |
| 7 | Hassan Haskins | Michigan | SR | RB | 10 | 2 | 2 | 2 | 1 | 0 | 0 | 0 |
| 7 | Evan Hull | N'western | SO | RB | 9 | 5 | 2 | 1 | 1 | 1 | 0 | 0 |
| 7 | Ivory Kelly-Martin | Iowa | SR | RB | 7 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 7 | Chester Kimbrough | Mich St | JR | CB | 8 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 7 | Adrian Martinez | Nebraska | JR | QB | 8 | 2 | 2 | 1 | 1 | 1 | 0 | 0 |
| 7 | Malick Meiga | Penn State | FR | WR | 6 | 1 | 1 | 1 | 1 | 0 | 0 | 0 |
| 7 | Chris Olave | Ohio State | SR | WR | 9 | 8 | 3 | 2 | 1 | 0 | 0 | 0 |
| 7 | Jayden Reed | Mich St | JR | WR | 9 | 5 | 2 | 1 | 1 | 0 | 0 | 0 |
| 7 | Jaxon Smith-Njigba | Ohio State | SO | WR | 9 | 6 | 4 | 2 | 1 | 1 | 0 | 0 |
| 7 | Malik Washington | N'western | JR | WR | 9 | 3 | 3 | 1 | 1 | 0 | 0 | 0 |
| 7 | Miyan Williams | Ohio State | FR | RB | 7 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Garrett Wilson | Ohio State | JR | WR | 8 | 4 | 3 | 3 | 1 | 1 | 0 | 0 |
| 7 | Roman Wilson | Michigan | SO | WR | 9 | 4 | 1 | 1 | 1 | 1 | 0 | 0 |
| 7 | Jaquez Yant | Nebraska | FR | RB | 6 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
| 7 | Craig Young | Ohio State | SO | SAF | 9 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |